Chemical biology, synthetic biology and multi-omics tools to read, write and repair the genome.以化学生物学、合成生物学与多组学工具读取、编写与修复基因组。
We develop chemical-biology and synthetic-biology tools to interrogate how site-specific histone modifications shape chromatin structure and gene regulation in living cells. By combining genetically encoded photoaffinity probes, crosslinking proteomics and genome-wide sequencing, we built the SiTomics platform — a single-site-resolved multi-omics strategy that links the chromatinized proteome to the genome, and revealed the central role of super-enhancers in the metabolite–modification–transcription axis.我们发展化学生物学与合成生物学工具，研究位点特异的组蛋白修饰如何在活细胞中塑造染色质结构与基因调控。通过整合遗传编码光交联探针、交联蛋白质组学与全基因组测序，我们建立了 SiTomics 单位点分辨多组学平台，实现染色质化蛋白质组与基因组的直接关联，并揭示超级增强子在“代谢–修饰–转录”调控轴中的重要作用。
We design precise genome- and cell-based therapies that target the root genetic cause of inherited disorders. Our recent work applied adenine base editing to correct the most common PEX1 variant causing Zellweger spectrum disorder, restoring peroxisome and liver function in vivo and in patient-derived cells, and provided the deaminase that was subsequently used in a first-in-human personalised gene-editing treatment.我们设计精准的基因组与细胞治疗方案，靶向遗传性疾病的根本病因。近期工作利用腺嘌呤碱基编辑修正导致 Zellweger 谱系障碍的最常见 PEX1 突变，在动物体内与患者来源细胞中恢复了过氧化物酶体与肝脏功能，并提供了后续用于首例个体化基因编辑治疗的脱氨酶组件。
How do repetitive elements and transposable elements shape genome architecture and regulatory innovation across species? We combine comparative genomics, AI-assisted sequence analysis and stem-cell platforms to trace the evolutionary trajectories of regulatory elements, and to ask how genome organisation constrains or enables gene regulation.重复序列与转座元件如何塑造跨物种的基因组结构与调控创新？我们结合比较基因组学、AI 辅助序列分析与干细胞平台，追溯调控元件的演化轨迹，并探究基因组组织方式对基因调控的约束与赋能作用。