Welcome课题组简介
FQ Research Group is based at the School of Synthetic Biology and Biomanufacturing, Tianjin University. We develop next-generation tools for cell engineering and therapeutic intervention, combining chemical biology, synthetic biology and multi-omics to read, write and repair the genome. Our work spans chromatin spatial proteomics, precision base editing and cross-species genome evolution.秦芳菲课题组依托天津大学合成生物与生物制造学院，致力于开发面向细胞工程与治疗干预的下一代工具。课题组融合化学生物学、合成生物学与多组学手段，实现对基因组的读取、编写与修复，研究覆盖染色质空间蛋白质组学、精准碱基编辑与跨物种基因进化。
By integrating genetically encoded chemical probes, single-molecule imaging and genome editing, we aim to understand how metabolites, chromatin marks and genome architecture are connected — and to turn that understanding into therapies for inherited disease.通过整合遗传编码化学探针、单分子成像与基因组编辑技术，我们力图理解代谢物、染色质修饰与基因组结构之间的内在联系，并将这些认识转化为遗传性疾病的治疗策略。
Research Highlights研究方向概览
Read more →查看详情 →Chromatin Dynamics染色质动态机制
Chromatin DynamicsSite-resolved multi-omics to map how histone modifications define the chromatinized proteome and genome in living cells.以单位点分辨多组学解析组蛋白修饰如何在活细胞中定义染色质化的蛋白质组与基因组。
Learn more →了解更多 →Gene & Cell Therapy基因与细胞疗法
Gene & Cell TherapyBase-editing strategies that correct pathogenic variants causing inherited disorders, from molecular mechanism to in vivo rescue.开发碱基编辑策略，精准修正遗传性疾病的致病突变，从分子机制到体内功能挽救。
Learn more →了解更多 →Genome Evolution基因组进化
Genome EvolutionRepetitive and transposable elements, AI-assisted computation and stem-cell platforms to trace genome evolution across species.聚焦重复序列与转座元件，结合 AI 计算与干细胞平台，探索跨物种基因进化规律。
Learn more →了解更多 →Selected Publications代表性论文
All publications →全部论文 →-
Linking chromatin acylation mark-defined proteome and genome in living cells.Fangfei Qin et al. · Cell, 2023, 186(5), 1066-1085.秦芳菲 等 · Cell, 2023, 186(5), 1066-1085.
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In vivo base editing rescues liver pathophysiology and peroxisome dysfunction in a mouse model of Zellweger spectrum disorder.Xin D. Gao, Maximiliano Presa, ... Fangfei Qin ... David R. Liu · Nature Biomedical Engineering, 2026.Xin D. Gao, Maximiliano Presa, ... 秦芳菲 ... David R. Liu · Nature Biomedical Engineering, 2026.
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The transcriptional coactivator RUVBL2 regulates Pol II clustering with diverse transcription factors.Hui Wang, ... Fangfei Qin ... Xiong Ji · Nature Communications, 2022, 13, 5703.王辉, ... 秦芳菲 ... 季雄 · Nature Communications, 2022, 13, 5703.